Protein Purification
Sino Biological Mouse CD4 Protein (ECD, His Tag), Endotoxin-Free 100µg
A DNA sequence encoding the extracellular domain of mouse CD4 (NP_038516.1) (Met 1-Thr 394) was expressed, fused with a polyhistidine tag at the C-terminus.
Sino Biological Human CD14 Protein (His Tag), Endotoxin-Free 100µg
A DNA sequence encoding the mature form of human CD14 (NP_000582.1) (Met 1-Met 344) was fused with a polyhistidine tag at the C-terminus.
Cayman Chemical HIV1 Integrase InhIbItr 1 25mg
An inhibitor of HIV-1 integrase DNA strand transfer (IC50 = 14 nM); an inhibitor of SARS-CoV-2 Mpro at 10 µM in a fluorescence-based assay; decreases SARS-CoV-2 replication (EC50 = 0.27 µM) and reduces PFUs in infected Huh7.5 cells in a concentration-dependent manner
CPC Scientific H-Ser-Phe-Leu-Leu-Arg-Asn-OH (trifluoroacetate salt) 5MG
This peptide is the fragment 42-47 of the thrombin receptor, which acts as a thrombin receptor activator. It is effective in causing tyrosine phosphorylation, inhibition of cAMP formation, and an increase in cytosolic Ca2+.SEQUENCE: H-Ser-Phe-Leu-Leu-Arg-Asn-OH (trifluoroacetate salt)ONE-LETTER SEQUENCE: SFLLRNMOLECULAR FORMULA: C34H56N10O9MOLECULAR WEIGHT: 748.88STORAGE CONDITIONS: -20 5 CCAS REGISTRY NUMBER: [141136-83-6]SYNONYMS: Thrombin Receptor Activator Peptide 6, Thrombin Receptor (1-6) (human), PAR-1 (1-6) (human), Proteinase Activated Receptor 1 (1-6) (human), SFLLRN, Coagulation Factor II Receptor (1-6) (human)RESEARCH AREA: HematologyREFERENCES:L.F.Brass et al., J. Biol. Chem., 269, 2943 (1994)R.Kaufmann et al., NeuroReport, 9, 709 (1998)B.A.Olson et al., Pharmacology, 58, 200 (1999)H.Andersen et al., Proc. Natl. Acad. Sci. USA, 96, 11189 (1999)R.Kaufmann et al., J. Neurooncol., 42, 131 (1999)C.-C.Wu et al., Br. J. Pharmacol., 130, 1289 (2000)H.
Apexbio Technology LLC Gliotoxin 67-99-2 5mg
Gliotoxin (CAS 67-99-2) is a small-molecule inhibitor targeting the chymotrypsin-like activity of the 20S proteasome farnesyltransferase (IC50 80 M) and geranylgeranyltransferase I (IC50 17 M) It modulates protein prenylation pathways and proteasomal function thereby regulating processes involved in tumor cell proliferation and immune cell functionality Gliotoxin exerts its biological activity primarily through inhibition of these enzymes and by modulating host-pathogen interactions including suppression of macrophage phagocytic function and facilitating Aspergillus internalization in lung epithelial (A549) cells via activation of host phospholipase D In vitro studies demonstrate growth inhibition of human breast cancer cells Based on these pharmacological properties gliotoxin holds research potential in cancer biology proteasome function fungal pathogen-host cell interaction and cellular signaling pathway studies